Baseline Participant Characteristics are Associated With Engagement in a Movement-Based RCT for Chronic Low-Back Pain.
PurposeExamine whether baseline participant characteristics predict engagement in a movement-based RCT for chronic low back pain (CLBP).DesignLongitudinal study within an RCT.SettingOnline.Subjects138 individuals with CLBP (18-79 years).InterventionParticipants were randomized to a […]
App-Based Coaching to Prevent Addictive Behaviors in Vocational School Students: A Cluster Randomized Trial.
This two-arm cluster randomized controlled trial evaluated the effectiveness of an app-based addiction prevention program in German vocational school students. Schools from 5 German federal states were recruited. No eligibility […]
The impact of recreational cannabis retailer allocation on emergency department visits: A natural experiment utilizing lottery design.
In October 2018, Canada legalized recreational cannabis, with Ontario distributing retailer licenses through a lottery system in 2019. This study investigates the impact of recreational cannabis retailer allocation on emergency […]
A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women.
Cannabidiol (CBD), a specialized metabolite (phytocannabinoid) abundant in Cannabis sativa, is attracting increasing attention for its alleged health-promoting properties. The present study aimed to investigate the pharmacokinetics of CBD and […]
Effects of randomization to buprenorphine or naltrexone for OUD on cannabis use outcomes: A secondary analysis of the X:BOT trial.
Cannabis use is highly prevalent in patients seeking treatment for opioid use disorder. Studies have shown mixed results on the association between cannabis use and opioid use as well as […]
CB Receptor Antagonist Selonabant (ANEB-001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial.
Emergency department visits due to cannabinoid-induced toxicity, including acute cannabinoid intoxication (ACI) have increased worldwide as more states have liberalized cannabis policy. ACI symptoms include anxiety, panic attacks, tachycardia, and […]
Youth experiencing homelessness at risk for suicide: psychosocial risk factors and service use patterns.
Young adults experiencing homelessness often suffer from adverse mental health outcomes and suicide is a leading cause of death. The objective of this study is to examine service use and […]
N-acetylcysteine for youth cannabis use disorder: randomized controlled trial main findings.
Cannabis use disorder is particularly prevalent and impairing among young people, and evidence-based treatments are limited. Prior trials of N-acetylcysteine, added to contingency management as a platform behavioral intervention, yielded […]
UK Medical Cannabis Registry: An Analysis of Clinical Outcomes of Medicinal Cannabis Therapy for Cancer Pain.
Cancer pain (CP) is a prevalent condition with limited pharmacotherapeutic options. Cannabis-based medicinal products (CBMPs) have shown analgesic effects, but their efficacy in CP remains contentious. This study aims to […]
Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study.
Traditional treatment approaches for prescription-type opioid use disorder (POUD), centered on abstinence, have limitations and hinder the development of interventions that meet the needs of people with POUD. Reduction in […]
Mindfulness-based relapse prevention for cannabis regular users: Finally outcomes of a randomized clinical trial.
Cannabis is the most widely used drug in the world, and the therapies proposed to help withdrawal are moderately effective. The MACBETH project is a pilot study in France. It […]
Socio-economic status and the effect of guideline-directed medical therapy in the STRONG-HF study.
Acute heart failure (AHF) impacts millions globally, with outcomes varying based on socio-economic status (SES). SES measured by annual household income, years of education and medical insurance coverage. Each patient’s […]
Evaluation of iSTART: A Novel Substance Use Prevention Web-App Designed for Diverse College Students.
There is little research assessing substance use prevention programs designed for first generation, working, and ethnic minority college students. This study assessed the effectiveness of a multi-substance web-app prevention program […]
Change in Cigarette, Other Tobacco Product, and Cannabis Use Among Individuals Who Used or Did Not Use Cannabis During a Smoking Cessation Trial.
As many as 40% of adults who smoke (AWS) use cannabis, yet little is known about how cigarette-cannabis (CIG-CAN) use impacts change in cigarette and other tobacco product (OTP) use […]
The Pharmacokinetics and Pharmacodynamics of a Hemp-Derived “Full-Spectrum” Oral Cannabinoid Product with a 1:1 Ratio of Cannabidiol to Cannabidiolic Acid and Delta-9-Tetrahydrocannabinol to Delta-9-Tetrahydrocannabinolic Acid: A Double-Blind, Placebo-Controlled, Within-Subjects Human Laboratory Study.
To examine the acute pharmacokinetics (PK) and pharmacodynamics (PD) of a patented oral cannabinoid product containing a botanical hemp-derived “full-spectrum” extract with an approximate 1:1 ratio of cannabidiol (CBD) to […]
Long-term safety and effectiveness of fenfluramine in children and adults with Dravet syndrome.
We analyzed the long-term safety and effectiveness of fenfluramine (FFA) in patients with Dravet syndrome (DS) in an open-label extension (OLE) study after participating in randomized controlled trials (RCTs) or […]
The appetite stimulating effect and safety of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in older patients with poor appetite: A triple-blinded, randomized, placebo-controlled, cross-over trial.
Anorexia of aging is prevalent and constitutes a significant factor in the onset of malnutrition with limited effective interventions. Cannabis-based medicine (CBM) with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may have […]
Cannabidiol attenuates precuneus activation during appetitive cue exposure in individuals with alcohol use disorder.
Alcohol use disorder (AUD) is a prevalent psychiatric condition characterised by problematic alcohol consumption and craving, necessitating the exploration of novel therapeutic interventions. Cannabidiol (CBD), a non-psychoactive component of cannabis, […]