Cannabis Use Cessation and the Risk of Psychotic Disorders: A Case-Control Analysis from the First Episode Case-Control EU-GEI WP2 Study: L’arrêt de l’utilisation du cannabis et le risque de troubles psychotiques: Une analyse cas-témoins tirée de l’étude cas-témoins EU-GEI WP2 centrée sur les premiers épisodes psychotiques.
To establish whether the risk of psychotic disorders in cannabis users changes with time following cannabis cessation using data from the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI) case-control study. The EU-GEI case-control study collected data from first episode psychosis patients and population controls across sites in Europe and Brazil between […]
Endoscopic retrograde cholangiopancreatography training using a silicone simulator fabricated using a 3D printing technique (with videos).
Endoscopic retrograde cholangiopancreatography (ERCP) training remains challenging. This study used 3D printing techniques to develop and optimize a portable ERCP training simulator and to implement basic and advanced practical techniques. Subsequently, we aimed to determine whether endoscopy trainees acquired proficiency in ERCP techniques and assess any improvements in their skill levels from using this model. […]
Factors predicting manipulation under anaesthesia after total knee replacement.
Manipulation under anesthesia (MUA) is a standard and effective treatment to correct stiffness and improve range of motion (ROM) following total knee arthroplasty (TKA). Delayed MUA has been associated with increased rates of revision surgeries and infections. Early MUA has been shown to double the mean gain in flexion compared to delayed interventions. To identify […]
Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors.
Previous studies identified clusters of first-episode psychosis (FEP) patients based on cognition and premorbid adjustment. This study examined a range of socio-environmental risk factors associated with clusters of FEP, aiming a) to compare clusters of FEP and community controls using the Maudsley Environmental Risk Score for psychosis (ERS), a weighted sum of the following risks: […]
Redefining preoperative imaging-based localization of adenomas in primary hyperparathyroidism patients candidates for minimally invasive surgery.
To compare the diagnostic accuracy of [F]-Fluorocholine (FCH) PET/CT with conventional [mTc]Tc-MIBI scintigraphy and cervical ultrasound (USG) for the preoperative localization of hyperfunctioning parathyroid tissue (HFPT) in patients with primary hyperparathyroidism (PHPT). This prospective study included 90 patients diagnosed with PHPT who underwent [F]F-CH PET/CT, [mTc]Tc-MIBI SPECT/CT and Neck USG. The diagnostic accuracy of each […]
In vivo capsular bag size in children with congenital cataract: implications for placement of intraocular lens.
To measure the equatorial lens diameter in vivo and correlate it with other biometric variables in children undergoing cataract surgery. Tertiary care institution. Prospective case series. Children younger than 5 years with cataracts were included. Those with corneal opacities, previous ocular surgery, traumatic cataracts, and/or any coexisting corneal or retinal ocular pathology were excluded. In […]
Cannabinoids in hair and their prospective association with mental and physical health outcomes in adolescents.
Cannabis is one of the most widely used drugs in early adolescence, a crucial time for development. Cannabinoids within the cannabis plant (e.g., delta-9-tetrahydrocannabinol [THC], and cannabidiol [CBD]) are suggested to have a range of health implications. These may differ by sex, given sex differences in the endocannabinoid system (ECS). Yet, how aspects of mental […]
Sloughing Esophagitis in the Pediatric Age Group: Clinicopathologic Characteristics of 12 Cases.
Sloughing esophagitis (esophagitis dissecans superficialis) is a benign, self-limited condition of uncertain etiology. It is most common in adults; pediatric literature is limited. Ten years of records were queried for esophageal biopsies containing terms “sloughing” and/or “dissecans.” Histologic inclusion criteria were “two-tone” appearance, sloughing/flaking of superficial epithelium, and parakeratosis. Degree of inflammation was documented and […]
Impacts of vaping and marijuana use on airway health as determined by exhaled breath condensate (EBC).
Across the United States, there is increased use of cannabis products and electronic delivery systems for cannabis products and nicotine, yet little is known about their impacts on lung health. We analyzed exhaled breath condensate of 254 participants who were non-users and users who used cannabis and tobacco products. The 132 participants reported using a […]
Pain predicts past-month co-use of alcohol and cannabis among emerging adults: Results from the Population Assessment of Tobacco and Health (PATH) Study.
Alcohol use, cannabis use, and pain are public health concerns among emerging adults (18-24 years old). Co-use of alcohol and cannabis is of particular concern since individuals who co-use alcohol and cannabis use more of each substance and experience greater substance-related harm. Pain and substance use frequently co-occur, and a growing body of literature indicates […]
Assessing the association between ADH5 and ALDH1A1 genetic variants and substance use disorder risk in a Jordanian male population.
Substance Use Disorder (SUD) is a severe global problem that is influenced by both environmental and genetic factors. The genetic etiology of addiction can be complex and overlapping. This study aimed to investigate the association between two genes, ADH5 and ALDH1A1, and drug addiction in Jordanian males. This study included 496 addicted patients and 496 […]
Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism.
Pathogenic hexanucleotide repeat expansions in C9orf72 are the commonest genetic cause of frontotemporal dementia and/or amyotrophic lateral sclerosis. There is growing interest in intermediate repeat expansions in C9orf72 and their relationship to a wide range of neurological presentations, including Alzheimer’s disease, Parkinson’s disease, progressive supranuclear palsy, corticobasal degeneration, and corticobasal syndromes. To assess the prevalence […]
Appropriate excision surgery reduces intrahepatic bile duct dilatation in pediatric patients with congenital biliary dilatation.
This study aims to assess the long-term postoperative changes in the preoperative dilated intrahepatic bile duct (IHBD) in pediatric patients with congenital biliary dilatation (CBD). The postoperative serial changes in the preoperative dilated left IHBD in pediatric patients who underwent appropriate excision surgery were evaluated using magnetic resonance cholangiopancreatography (MRCP). The IHBD dilation significantly decreased […]
Short- and mid-term outcomes after redo surgical valve replacement.
While previous studies have indicated comparable outcomes for redo surgical valve replacement (SVR) and primary SVR, there is limited information regarding the long-term follow-up of these patients. Providing prognostic data on redo SVR is crucial for enhancing decision-making and medical care, as well as for identifying low-risk subsets of patients eligible for redo SVR. This […]
Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses.
This study investigated the genetic and epigenetic mechanisms underlying the comorbidity of five substance dependence diagnoses (SDs; alcohol, AD; cannabis, CaD; cocaine, CoD; opioid, OD; tobacco, TD). A latent class analysis (LCA) was performed on 22,668 individuals from six cohorts to identify comorbid DSM-IV SD patterns. In subsets of this sample, we tested SD-latent classes […]
Effect of biliopancreatic tree anatomy on development of acute gallstone pancreatitis.
Acute pancreatitis (AP) is a complex disorder with gallstones being the most common underlying cause. Anatomical variations of gallbladder, cystic duct (CD), common bile duct and main pancreatic duct and their courses and interactions with each other have been studied and shown to be related to development of AP in various studies. With this study, […]
Lung Transplantation From Donors With a History of Substance Use.
Substance use is common among lung transplant donors, but concerns persist about graft damage. Stimulant drugs such as cocaine and methamphetamine can induce pulmonary arterial hypertension, while smoked products such as cannabis and crack cocaine can produce airway and parenchymal diseases. We sought to characterize donor substance use at our center and evaluate the associations […]
Total hospital cost of robot-assisted approach in major urological cancer surgeries.
The aim of this study was to test for differences in total hospital cost (THC) between robot-assisted vs. open partial nephrectomy (PN), radical cystectomy (RC), radical prostatectomy (RP) and radical nephroureterectomy (NU). Within the National Inpatient Sample (2010-2019), we identified all robot-assisted vs. open PN, RC, RP and NU patients. Multivariable Poisson regression models were […]