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Evidence Review

Cannabis evidence for Cardiology

Across 128 cannabis studies indexed for Cardiology, the strongest available evidence is strong (Grade A); the mean BoC Evidence Strength score is 51/100.

51 Mean evidence score / 100

A Strong 3

B Moderate 38

C Limited 58

D Emerging 29

The Evidence Landscape

Cardiology studies, by strength & recency

A B C D Trial Bubble size = sample size

The studies

Strongest evidence first

Cardiology

Cannabis use and atherosclerotic cardiovascular disease outcomes: A meta-analysis of multinational cohort data.

Disease-a-month : DM · 2025

Meta-Analysis n=1,902,481

Cardiology

Cannabis use and atrial arrhythmias: A systematic review and meta-analysis of large populational studies.

Heart rhythm · 2025

Meta-Analysis n=90,195

Cardiology

A systematic review and meta-analysis of randomized controlled trials of cardiovascular toxicity of medical cannabinoids.

Journal of the American Pharmacists Association : JAPhA · 2021

Meta-Analysis n=2,800

Cardiology

Effects of CBD supplementation on ambulatory blood pressure and serum urotensin-II concentrations in Caucasian patients with essential hypertension: A sub-analysis of the HYPER-H21-4 trial.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023

RCT n=51

Cardiology

CBD supplementation reduces arterial blood pressure via modulation of the sympatho-chromaffin system: A substudy from the HYPER-H21-4 trial.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023

RCT n=54

Cardiology

What is the Current Knowledge About the Cardiovascular Risk for Users of Cannabis-Based Products? A Systematic Review.

Current atherosclerosis reports · 2017

Systematic Review n=116

Cardiology

Marijuana use and acute myocardial infarction: A systematic review of published cases in the literature.

Trends in cardiovascular medicine · 2019

Systematic Review n=62

Cardiology

Increased Risks of Major Cardiac Adverse Events in Stimulant Use Disorder as Compared With Other Substance Use Disorders: A Propensity-score Matching Cohort Study.

Journal of addiction medicine · 2025

n=137,106

Cardiology

The Risk of Ventricular Septal Defects Associated With Prenatal Marijuana Exposure: A Systematic Review and Meta-Analysis.

Cardiology in review · 2024

Meta-Analysis

Cardiology

Outcomes in patients with acute myocardial infarction and history of illicit drug use: a French nationwide analysis.

European heart journal. Acute cardiovascular care · 2021

n=3,381,472

Cardiology

The Association Between Cannabis Use and Electrocardiographic Abnormalities in People Living With HIV.

Journal of acquired immune deficiency syndromes (1999) · 2026

n=3,610

Cardiology

The Association of Cannabis Use Disorder with Acute Limb Ischemia and Critical Limb Ischemia.

Vascular and endovascular surgery · 2022

n=824,856

Cardiology

Marijuana and thromboembolic events in geriatric trauma patients: The cannabinoids clots correlation!

American journal of surgery · 2021

n=2,835

Cardiology

Lifetime Cannabis Use and Incident Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Hypertension (Dallas, Tex. : 1979) · 2025

n=4,328

Cardiology

Cannabis use and incident atrial fibrillation in a longitudinal cohort.

Heart rhythm · 2023

n=150,554

Cardiology

Trends in urine drug screening and positivity among patients with heart failure: Insights from a large health system.

American heart journal · 2025

n=75,164

Cardiology

Impact of Prenatal Cannabis Use Disorder on Perinatal Outcomes.

Journal of addiction medicine · 2022

n=2,380,446

Cardiology

Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study.

BMC cardiovascular disorders · 2023

Meta-Analysis

Cardiology

Cardiovascular risk associated with the use of cannabis and cannabinoids: a systematic review and meta-analysis.

Heart (British Cardiac Society) · 2025

Meta-Analysis

Cardiology

The effects of cannabis use on major adverse cardiovascular outcomes, mortality, cost of hospitalization, and cardiac arrhythmias: A Retrospective analysis using the national inpatient sample.

Current problems in cardiology · 2024

n=39,992

Cardiology

Substance Use Disorder as Risk Factor for Intubation in Angioedema: A Nationwide Cohort Study.

The Laryngoscope · 2024

n=117,509

Cardiology

Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011.

The Journal of pediatrics · 2021

n=11,020

Cardiology

Hemp seed protein and its hydrolysate compared with casein protein consumption in adults with hypertension: a double-blind crossover study.

The American journal of clinical nutrition · 2024

RCT n=35

Cardiology

A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity.

BMJ open · 2017

RCT n=50

Explore all Cardiology research in the repository →

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Cannabis evidence for Cardiology

Cardiology studies, by strength & recency

Strongest evidence first

Cannabis use and atherosclerotic cardiovascular disease outcomes: A meta-analysis of multinational cohort data.

Cannabis use and atrial arrhythmias: A systematic review and meta-analysis of large populational studies.

A systematic review and meta-analysis of randomized controlled trials of cardiovascular toxicity of medical cannabinoids.

Effects of CBD supplementation on ambulatory blood pressure and serum urotensin-II concentrations in Caucasian patients with essential hypertension: A sub-analysis of the HYPER-H21-4 trial.

CBD supplementation reduces arterial blood pressure via modulation of the sympatho-chromaffin system: A substudy from the HYPER-H21-4 trial.

What is the Current Knowledge About the Cardiovascular Risk for Users of Cannabis-Based Products? A Systematic Review.

Marijuana use and acute myocardial infarction: A systematic review of published cases in the literature.

Increased Risks of Major Cardiac Adverse Events in Stimulant Use Disorder as Compared With Other Substance Use Disorders: A Propensity-score Matching Cohort Study.

The Risk of Ventricular Septal Defects Associated With Prenatal Marijuana Exposure: A Systematic Review and Meta-Analysis.

Outcomes in patients with acute myocardial infarction and history of illicit drug use: a French nationwide analysis.

The Association Between Cannabis Use and Electrocardiographic Abnormalities in People Living With HIV.

The Association of Cannabis Use Disorder with Acute Limb Ischemia and Critical Limb Ischemia.

Marijuana and thromboembolic events in geriatric trauma patients: The cannabinoids clots correlation!

Lifetime Cannabis Use and Incident Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Cannabis use and incident atrial fibrillation in a longitudinal cohort.

Trends in urine drug screening and positivity among patients with heart failure: Insights from a large health system.

Impact of Prenatal Cannabis Use Disorder on Perinatal Outcomes.

Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study.

Cardiovascular risk associated with the use of cannabis and cannabinoids: a systematic review and meta-analysis.

The effects of cannabis use on major adverse cardiovascular outcomes, mortality, cost of hospitalization, and cardiac arrhythmias: A Retrospective analysis using the national inpatient sample.

Substance Use Disorder as Risk Factor for Intubation in Angioedema: A Nationwide Cohort Study.

Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011.

Hemp seed protein and its hydrolysate compared with casein protein consumption in adults with hypertension: a double-blind crossover study.

A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity.

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Cannabis evidence for Cardiology

Cardiology studies, by strength & recency

Strongest evidence first

Cannabis use and atherosclerotic cardiovascular disease outcomes: A meta-analysis of multinational cohort data.

Cannabis use and atrial arrhythmias: A systematic review and meta-analysis of large populational studies.

A systematic review and meta-analysis of randomized controlled trials of cardiovascular toxicity of medical cannabinoids.

Effects of CBD supplementation on ambulatory blood pressure and serum urotensin-II concentrations in Caucasian patients with essential hypertension: A sub-analysis of the HYPER-H21-4 trial.

CBD supplementation reduces arterial blood pressure via modulation of the sympatho-chromaffin system: A substudy from the HYPER-H21-4 trial.

What is the Current Knowledge About the Cardiovascular Risk for Users of Cannabis-Based Products? A Systematic Review.

Marijuana use and acute myocardial infarction: A systematic review of published cases in the literature.

Increased Risks of Major Cardiac Adverse Events in Stimulant Use Disorder as Compared With Other Substance Use Disorders: A Propensity-score Matching Cohort Study.

The Risk of Ventricular Septal Defects Associated With Prenatal Marijuana Exposure: A Systematic Review and Meta-Analysis.

Outcomes in patients with acute myocardial infarction and history of illicit drug use: a French nationwide analysis.

The Association Between Cannabis Use and Electrocardiographic Abnormalities in People Living With HIV.

The Association of Cannabis Use Disorder with Acute Limb Ischemia and Critical Limb Ischemia.

Marijuana and thromboembolic events in geriatric trauma patients: The cannabinoids clots correlation!

Lifetime Cannabis Use and Incident Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Cannabis use and incident atrial fibrillation in a longitudinal cohort.

Trends in urine drug screening and positivity among patients with heart failure: Insights from a large health system.

Impact of Prenatal Cannabis Use Disorder on Perinatal Outcomes.

Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study.

Cardiovascular risk associated with the use of cannabis and cannabinoids: a systematic review and meta-analysis.

The effects of cannabis use on major adverse cardiovascular outcomes, mortality, cost of hospitalization, and cardiac arrhythmias: A Retrospective analysis using the national inpatient sample.

Substance Use Disorder as Risk Factor for Intubation in Angioedema: A Nationwide Cohort Study.

Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011.

Hemp seed protein and its hydrolysate compared with casein protein consumption in adults with hypertension: a double-blind crossover study.

A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity.

Other conditions

Anxiety

Pain

Oncology

Epilepsy

Inflammation

Neurology

Sleep

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