Carbon monoxide (CO) poisoning continues to result in hospitalization and mortality. We sought to analyze risk factors associated with inpatient admission for CO poisoning. Retrospective study of the US National Inpatient Sample (NIS) database. All adults with ICD-10 code for CO poisoning from 01/01/2016 to 12/31/2020 were identified. Demographics, co-morbid conditions, insurance type, household income, length of stay (LOS), total charges, and mortality were abstracted. Univariable logistic regression was used to calculate unadjusted odds ratios (ORs) for CO poisoning admissions.