Reports of low semen quality have led to investigations of potential risk factors, including cannabis use. Cannabis affects the endocannabinoid system, which in part regulates spermatogenesis and hormonal balance, but evidence on its impact on male reproductive health remains inconsistent. This study examined the associations between ever cannabis use and biomarkers of male fecundity in a large cohort of young Danish men incorporating detailed information on their concurrent health behaviors and potential confounding factors during fetal life, a key limitation…