A within-subject cross-over trial comparing the acute effects of oral delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in healthy adults.
Oral products containing Δ8-tetrahydrocannabinol (Δ8-THC), a chemical isomer of the primary psychoactive consistent of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), have increased in popularity in recent years. The behavioral effects and pharmacokinetics of oral Δ8-THC remain poorly characterized. Nineteen healthy adults with no past-month cannabinoid exposure completed five randomized outpatient sessions in a within-subjects, double-blind, crossover design. Participants […]
Total hospital cost of robot-assisted approach in major urological cancer surgeries.
The aim of this study was to test for differences in total hospital cost (THC) between robot-assisted vs. open partial nephrectomy (PN), radical cystectomy (RC), radical prostatectomy (RP) and radical nephroureterectomy (NU). Within the National Inpatient Sample (2010-2019), we identified all robot-assisted vs. open PN, RC, RP and NU patients. Multivariable Poisson regression models were […]
The impact of acetazolamide and dronabinol on the physiological endotypes responsible for obstructive sleep apnea.
To investigate the effect of differing doses of the combination of acetazolamide and dronabinol (Aceta-Dro) on the obstructive sleep apnea (OSA) endotypes and their relationship to OSA severity. We retrospectively analysed data from a double-blind, randomized, placebo-controlled trial of 3 different doses of Aceta-Dro [Low(125mg/2.5 mg), Medium(250mg/5 mg), High(500mg/10 mg)] in OSA patients. OSA endotypes (collapsibility [V], Loop […]
A within-subject cross-over trial comparing the acute effects of vaporized delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in healthy adults.
The prevalence and accessibility of Δ8-tetrahydrocannabinol (Δ8-THC), a chemical isomer of Δ9-tetrahydrocannabinol (Δ9-THC), has increased drastically, yet no controlled studies have directly compared the effects of vaporized Δ8-THC and Δ9-THC . Twenty healthy adults with no past-month cannabis exposure completed five randomized outpatient sessions in a within-subjects, double-blind, crossover design. Participants inhaled Δ8-THC (10, 20, […]
Feasibility and Tolerability of Nabilone for the Treatment of Obesity: A Randomized Controlled Pilot Trial.
In epidemiological studies, people who use cannabis have a lower prevalence of obesity. Furthermore, the endocannabinoid system is recognized as a potential target for obesity treatment and partial agonism of the cannabinoid type-1 (CB) receptor may reduce body weight. We thus hypothesized that 12 weeks of pharmacotherapy with the partial CB receptor agonist nabilone would […]
Effects of intravenous d9-THC on pupillary reaction and pupil size: a prospective, placebo-controlled trial in healthy volunteers not regularly consuming cannabis.
This prospective, single-blind, placebo-controlled trial examined the effects of intravenous delta-9-tetrahydrocannabinol (d9-THC) on the pupillary light reflex and pupil size in volunteers not regularly consuming cannabis. With ethics committee approval and written informed consent, healthy cannabis-naïve or abstinent volunteers were included. Fifteen volunteers received an intravenous bolus of d9-THC and four received placebo. Pupillary reaction […]
ADHD Symptoms and Medical Cannabis Use Among Adults With Chronic Pain.
We examined whether medical cannabis (MC) use was associated with change in ADHD symptoms across time in a sample of adults with chronic pain. We conducted a longitudinal cohort study ( = 223) across 12 months, assessing ADHD symptoms and MC use. We used mixed-effects linear regression to test whether MC use (vs. no use) and high THC […]
Young Adults Advancing Through the Stages of Change: A Mediational Analysis of Cannabis Use Disorder Treatment.
The Stages of Change (SoC) model explains addictive behavior change through 5 stages: precontemplation, contemplation, preparation, action, and maintenance. Limited evidence exists from randomized controlled trials testing the SoC model in Cannabis Use Disorder (CUD) treatments. The aim of this study was to test the indirect effects of Peer Network Counseling- text (PNC-txt), a text-message […]
The effect of a synthetic cannabinoid agonist (nabilone) on unimodal tactile illusion correlates with a psychometric scores in healthy volunteers.
Our previous studies showed that dexamphetamine, an indirect dopamine agonist, widens Stimulus Binding Windows (BWs) in healthy subjects. The present study aimed to investigate the effect of nabilone, a synthetic cannabinoid agonist, on the BWs in a unimodal illusion: the tactile funneling illusion (TFI). The study also aimed to study the association between tactile illusion […]
Renal vascular patterns assessment before robot-assisted partial nephrectomy: a video-based correlation with hilum dissection.
Surgical video review (SVR) is an emerging tool for assessing patient outcomes, especially in complex surgeries such as robot-assisted partial nephrectomy (RAPN). Adhesive probability and morphological scores are used to evaluate fat management and warm ischemia, respectively; however, the factors influencing renal hilum control (RHC) during RAPN have not yet been assessed. The aim of […]
Subjective drug-effect ratings predict cannabis self-administration in people who use cannabis daily.
As interest in the potential therapeutic benefits of cannabis-derived products grows, accurate predictors of abuse potential will be vital for informing regulatory decisions. Currently, the Food and Drug Administration recommends using subjective effect ratings of Drug Liking as the primary measure in human abuse potential studies. However, dissociations between subjective ratings and drug-taking behavior have […]
Risks of Cannabinoid Exposure on Birth Outcomes: A Systematic Review.
With the changing legal landscape, the acceptance and availability of cannabis products have increased. Cannabis products are generally considered “natural” and relatively safe by consumers. However, growing empirical evidence from humans and other animals indicates that cannabis negatively affects human health. In contrast to the well-known teratogenic effects of alcohol and tobacco products, the safety […]
Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.
This retrospective review aimed to evaluate the prevalence of tetrahydrocannabinol (THC)-positive urine drug screens (UDS) in patients undergoing chronic opioid therapy (COT) for chronic pain at a single academic institution. With a growing national trend toward cannabis legalization and increased public access to marijuana for medical and recreational purposes, understanding the intersection between THC use […]
Results for LINAC-based radiosurgery or fractionated stereotactic radiotherapy for corticotropic pituitary tumors: a single-center retrospective cohort.
Radiotherapy (RT) plays an important role in the treatment of persistent or recurrent Cushing disease (CD) after primary surgery. We assessed the results for RT using a linear accelerator based (LINAC) stereotactic technique. Primary objectives were progression-free survival (PFS) and time to hormonal disease control (THC). Single-center retrospective cohort in a tertiary, academic hospital assessed […]
Acute and chronic effects of medicinal cannabis use on anxiety and depression in a prospective cohort of patients new to cannabis.
Medicinal cannabis has mixed evidence for treating anxiety and depression, yet patients frequently use it as a treatment. This observational study evaluated the effects of medicinal cannabis initiation in adults with clinically significant anxiety and/or depression over a 6-month period. Adults with clinically significant anxiety and/or depression initiating medicinal cannabis use in Maryland, USA completed […]
Exploring the Impact of Chirality of Synthetic Cannabinoids and Cathinones: A Systematic Review on Enantioresolution Methods and Enantioselectivity Studies.
New psychoactive substances (NPSs) are emerging narcotics or psychotropics that pose a public health risk. The most commonly reported NPSs are synthetic cannabinoids and synthetic cathinones. Synthetic cannabinoids mimic the effects of Δ9-tetrahydrocannabinol (Δ9-THC), often with greater potency, while synthetic cathinones act as stimulants, frequently serving as cheaper alternatives to amphetamines, 3,4-methylenedioxymethamphetamine (MDMA) and cocaine. […]
Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis.
As cancer survival rates are increasing, alternative treatments to improve quality of life, such as cannabinoids, are gaining attention. Although cannabinoids are widely used to manage cancer-related symptoms, clear guidelines are lacking. This systematic review and meta-analysis assessed the safety and efficacy of cannabinoids in the management of symptoms among cancer patients. The study protocol […]
The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach.
Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay between childhood trauma, cannabis use, and paranoia using standard tetrahydrocannabinol (THC) units as a comprehensive measure of cannabis exposure. Data were derived from the Cannabis&Me study, […]